Peptide Nanoparticles as an Approach for Stable High Concentration Formulations

Peptides have emerged as a promising therapeutic modality, but present unique challenges are involved in formulation development, particularly at high concentrations that may be required for convenient administration routes such as subcutaneous injectable delivery, including: variable and potentially low solubility, precipitation, aggregation, high viscosity, among others
Stable peptide nanoparticles in water can enable stable and doseable formulations without the need for harsh excipients
A novel and general process has been identified for preparing peptide nanoparticles at high concentrations without causing stability risks or degradation, which works on a wide range of diverse peptide species.