Predicting Powder Flow Obstruction in Solid Dosage Form Manufacture

18 September 2023 11:40 - 12:10

  • Powder flow obstruction, such as arching or ratholing, is a prevalent occurrence in the manufacture of solid dosage forms.
  • Accurate prediction of powder flow obstruction requires the knowledge of both powder flowability and stress condition of the powder in the equipment.
  • The risk of powder flow obstruction is highest under the active stress state.  Traditional Jenike methodology in hopper design assumes the passive stress state and could therefore under-predict the powder flow risks.
  • Additional insights of powder flow risks, such as stress heterogeneity and flow pattern, can be obtained via FEM analysis.

Chen Mao, Distinguished Scientist, Small Molecule Pharmaceutical Sciences, Genentech