- Powder flow obstruction, such as arching or ratholing, is a prevalent occurrence in the manufacture of solid dosage forms.
- Accurate prediction of powder flow obstruction requires the knowledge of both powder flowability and stress condition of the powder in the equipment.
- The risk of powder flow obstruction is highest under the active stress state. Traditional Jenike methodology in hopper design assumes the passive stress state and could therefore under-predict the powder flow risks.
- Additional insights of powder flow risks, such as stress heterogeneity and flow pattern, can be obtained via FEM analysis.
Chen Mao, Distinguished Scientist, Small Molecule Pharmaceutical Sciences, Genentech