Impact of Bile Salts on Solubilization and Membrane Transport of Supersaturated Drug Formulations

14 December 2020 16:35 - 17:10

  • Supersaturating formulations have been developed to address the issues of inadequate aqueous solubility of new chemical entities and improve oral absorption
  • Bile salts, naturally present in the gastrointestinal tract, have been shown to impact the crystallization kinetics of supersaturated formulations
  • The effect of bile salt on thermodynamic properties of supersaturated drug solutions was evaluated. The interplay between solubilization and membrane transport was studied
  • The findings indicate that the impact of bile salts on solution thermodynamics is of relevance for improved understanding of in vivo performance of supersaturating dosage forms

Helen Hao Hou, Senior Scientist Small Molecule Pharmaceutical Sciences , Genentech