Extrusion is a polymer processing technology that is used in the solubilization technology known as Hot Melt Extrusion (HME) and a manufacturing technology to produce Long Acting Implants (LAIs). HME is an attractive processing technique to enhance the solubility of poorly water soluble drugs to enhance their bioavailability after oral administration. These crystalline hydrophobic drugs can be dispersed in hydrophilic polymers using HME to manufacture amorphous solid dispersions to improve their solubility and dissolution rate. Extrusion is increasingly used to produce LAIs varying in size, shape and release kinetics. This presentation will provide an overview of extrusion technology and review case studies of both HME and LAIs.