Melt-Extruded Dexamethasone Ophthalmic Implants: Process, Structure, and in vitro Drug Release

26 September 2022 12:15 - 12:45

  • Dexamethasone is dispersed in PLGA matrix as crystalline particles
  • Accurate dimension control is achieved with a two-step extrusion process and two-stage feeding with a purpose-built downstream puller.
  • Critical features of implants: diameter, pore size/distribution, and surface roughness
  • Tri-phasic drug release profiles with drug release controlled by the erosion of the implant matrix
The presentation discusses the (1) structure of dexamethasone implant, (2) in vitro release characteristics of dexamethasone implant, and (3) a manufacturing process for precise dimension and structure control.

Dr. Feng Zhang, Associate Professor Molecular Pharmaceutics and Drug Delivery , The University of Texas at Austin College of Pharmacy