New Insights in the Endothelial Transport of Orally Administered PEGylated Mixed Micelles

Mixed micelles from bile acids and phospholipids are currently used as oral formulations for poorly soluble drugs including vitamin K.
PEGylation improves the gastrointestinal colloidal stability and mucus penetration of mixed micelles.
PEGylated mixed micelles interact with Scavenger Receptor B1, imposing a mechanism for intestinal transport that may be used for other poorly soluble drugs.
Animal studies indicate that PEGylated mixed micelles may especially be useful to improve oral bioavailability in patients suffering from cholestasis.