New Insights in the Endothelial Transport of Orally Administered PEGylated Mixed Micelles

26 September 2022 10:15 - 10:45

  • Mixed micelles from bile acids and phospholipids are currently used as oral formulations for poorly soluble drugs including vitamin K.
  • PEGylation improves the gastrointestinal colloidal stability and mucus penetration of mixed micelles.
  • PEGylated mixed micelles interact with Scavenger Receptor B1, imposing a mechanism for intestinal transport that may be used for other poorly soluble drugs.
  • Animal studies indicate that PEGylated mixed micelles may especially be useful to improve oral bioavailability in patients suffering from cholestasis.