Predictive high-throughput screening of oligonucleotide lipid nanoparticle for gene silencing

26 September 2022 11:35 - 12:10

  • Automated high-throughput preparation and characterization of oligonucleotide-loaded lipid nanoparticles
  • Translatable performance between high-throughput prepared LNPs and scaled-up LNPs
  • A systematic PEG-lipids screening for LNP performance
  • LNP structural analysis by cryo-TEM and small-angle x-ray scattering

Chun-Wan Yen, Principal Scientist, Genentech