A single injection of a recombinant fusion loaded with rapamycin delivers effective zero-order absorption for one month

27 September 2022 09:40 - 10:15

  • Elastin-like polypeptides are humanized, repetitive peptides that undergo temperature-dependent phase separation
  • ELP fusion proteins can be designed to phase separate upon heating to physiological temperatures
  • When fused with the FKBP protein, ELPs can specifically bind and carry rapamycin
  • This formulation can be injected through a narrow-gauge needle and provide, while providing zero-order release for at least one month
  • Through pharmacokinetic and efficacy studies, this approach has been evaluated in multiple mouse models of disease

Professor Andrew Mackay, Gavin Herbert Associate Professor of Pharmaceutical Sciences, University of Southern California School of Pharmacy