Impact of Bile Salts on Solubilization and Membrane Transport of Supersaturated Drug Formulations

27 September 2022 10:15 - 10:45

  • Supersaturating formulations have been developed to address the issues of inadequate aqueous solubility of new chemical entities and improve oral absorption
  • Bile salts, naturally present in the gastrointestinal tract, have been shown to impact the crystallization kinetics of supersaturated formulations
  • The effect of bile salt on thermodynamic properties of supersaturated drug solutions was evaluated. The interplay between solubilization and membrane transport was studied
  • The findings indicate that the impact of bile salts on solution thermodynamics is of relevance for improved understanding of in vivo performance of supersaturating dosage forms