Preparation and evaluation of charge reversal solid lipid nanoparticles

27 September 2022 12:15 - 12:50

  • Design and investigate solid lipid nanoparticles (SLN) providing an intestinal alkaline phosphatase (IAP) triggered charge reversion.
  • The combination of a PEG-corona and P-PEG-surfactants seem to be an effective tool, to prepare nanoparticles exhibiting a charge reversal effect comparable to nanoemulsions, which represent the most promising charge reversal lipid-based drug delivery systems so far
  • Observed results indicated that a high amount of incorporated monophosphate ester was enzymatically cleaved resulting in the most effective IAP induced charge reversion by nanoparticles.
  • Charge reversal SLN might be a promising tool for nanoparticulate drug delivery across alkaline phosphatase bearing membranes that are covered by a mucus gel layer such as the intestine.